Book of Abstracts: Albany 2005

category image Volume 22
No. 6
June 2005

Wafer-fixed Polyvinylnucleobases, Homo- and Co-polymers: Their Synthesis, Characterization and Applications in Nanotechnology

Artificial homo- and co-polymeric polyvinylnucleobases with a polyvinyl backbone mimic native RNA, show the ability to hybridize to their complementary native nucleic acid strands, forming so-called more nuclease-resistant "semiplastic" double- and triple-stranded RNA analogues (1-3).

Physico-chemical investigations of these via thiol-gold linkage or by silylation procedure surface immobilized biologically active compounds show formation of uniform layers of molecules. The presented results of their chemical chain extensions allow us to propose new applications of "semiplastic" RNAs in the field of biochemical analysis and nucleic acid drugs.

Walter-Vesely Seb. Meister

PO Box: 900-239 (HPA)
Halle a.d. Saale
D-06054, Germany

Phone: ++ 49 - (0)178 - 8042699
Email: FloraMeraNitzschke@web.de

Figure 1: Wafer-fixed Co-polymeric Polyvinylnucleobases.

References and Footnotes
  1. Hoffmann, S. and Witkowski, W. Mesomorphic Order in Polymers and Polymerization in Liquid Crystalline Media Ed., Blumstein, A. ACS-Symp. Ser. 74, 178-236 (1978).
  2. Meister, W.-V., Lindau, S., Hauser, A. L., Bohley, Ch., Gromann, U., Naumann, St., Madre, M, Kovalenko, L., Bischoff, G., Zhuk, R., and Hoffmann, S. J. Biomol. Struct. Dyn. 18, 385-392 (2000).
  3. Meister, W.-V., Lindau, S., Hauser, A. L., Birch-Hirschfeld, E., Reinert, J., Friese, K., Bohley, Ch., Kargov, S. I., Gromann, U., and Hoffmann, S. Surf. Interface Anal. 33, 137-145 (2002).