The Lysozyme Model

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The Immune Response to Structurally Defined Proteins: The Lysozyme Model
Hardcover 1989

Editors: Sandra J. Smith-Gill & Eli E. Sercarz

ISBN 0-940030-27-6

Editorial Reviews
From Book News, Inc.
From a Workshop on the Immunology of Lysozyme, held in Bethesda, MD, June 1988, the purpose of which was to bring together the many investigators in diverse fields who are utilizing lysozyme as a model protein to investigate the immune response. Because this protein is so well characterized structurally, functionally, and immunologically, it is well suited for applications such as protein-protein interactions, vaccine development, antigen presentation, gene regulation, and antibody design by genetic engineering. All of these facets are summarized in this volume. Annotation copyright Book News, Inc. Portland, Or.

The Immune Response to Structurally Defined Proteins: The Lysozyme Model

Sandra J. Smith-Gill & Eli E. Sercarz

S. Smith-Gill and E. Sercarz

I. Lysozyme: The Protein

Structure and Physical Properties

Triclinic Lysozyme: Some Features of the Structure at 2Å Resolution
M. Ramanadham, L. C. Sieker and L. H. Jensen

X-Ray Refinement Studies on Monoclinic HEL Containing Two Independent Molecules at 1.8Å Resolution
C. Yu, S. T. Rao and M. Sundaralingam

The Folding of Hen Egg-White Lysozyme: An Immunochemical and Spectroscopy Study
M. E. Denton and H. A. Scheraga

Catalytic Function

The Use of Monoclonal Antibodies to Lysozyme in Mapping the Binding Sites for Saccharide Substrates Predicted from Conformational Energy Calculations
M. R. Pincus

Alteration of Substrate Preference of Hen Egg-White Lysozyme by Conversion of Trp62 Using Site-Directed Mutagenesis
I. Kumagai and K. Miura

Mechanistic and Evolutionary Studies on Genetically Engineered Chicken Lysozyme
J. F. Kirsch, B. A. Malcolm, M. J. Corey, L. Zhang and A. C. Wilson

Gene Regulation and Evolution

Transcriptional Regulation of the Chicken Lysozyme Gene
R. Renkawitz, A. Baniahmad, J. Altschmied, C. Steiner and M. Muller

Genes for Ruminant Lysozymes
D. M. Irwin, A. Sidow, R. Tyler White and A. C. Wilson

Electrophoretic Survey of Mouse Lysozymes with an Improved Way of Detecting Lysozyme Activity in Gels
G. A. Cortopassi and A. C. Wilson

Biological Functions

Structural Specificty of the Binding of Bacterial Lipopolysaccharide (LPS) to Hen Egg Lysozyme
N. Ohno and D. C. Morrison

Glycanated Lysozyme and Transglycanation
E. F. Osserman, G. Merlini, V. Bellotti, C. Gabel, G. Neri and D. Zopf

II. Molecular Recognition

Structure of Antibody:Protein Complexes

Three-Dimensional Structures of Two Fab Complexes with Lysozyme
D. R. Davies, S. Sheriff, E. A. Padlan, E. W. Silverton, G. H. Cohen and S. Smith-Gill

Structural Studies of Antibody:Lysozyme Complexes
R. A. Mariuzza, P. M. Alzari, A. G. Amit, G. A. Bentley, G. Boulot, V. Chitarra-Guillon, T. Fischmann, M.-B. Lascombe, M.-M. Rioottot, P. Saludjian, F. A. Saul, H. Souchon, D. Tello and R. J. Poljak

Recognitionof Protein Antigens by Antibodies: Crystal Structure of Antibody Fab Fragments Complexed with Influenza Virus Neuraminidase
W. G. Laver, R. G. Webster, P. J. Bossart, M. Luo and G. M. Air

Antibody:Protein Interactions

Structure-Function Relationships in High Affinity Antibodies to Lysozyme
T. B. Lavoie, L. N. W. Kam-Morgan, A. B. Hartman, C. P. Mallet, S. Sheriff, D. A. Saroff, C. R. Mainhart, P. A. Hamel, J. F. Kirsch, A. C. Wilson and S. J. Smith-Gill

Probing Molecular Recognition Using Simulation Methods
S. Subramaniam, J. A. McCammon and R. J. Bacquet

Epitope Mapping

Stryctural Aspects of the Immune Recognition of a Model Protein Antigen: Cytochrome c
Y. Paterson

III. Antigen Processing and Presentation, and the T Cell Response

Processing and Presentation of Lysozyme

Targeted Antigen Presentation: A Model to Investigate Endocytosis, Processing and Presentation of HEL by Normal Splenic B Cells
D. P. Snider, I. K. Uppenkamp, J. A. Titus and D. M. Segal

Stable Association of Naturally Processed Lysozyme with Antigen Presenting Cell Membranes
P. E. Jensen and G. S. Morris

Processing and Presentation of Self Idiotype in the Idiotype-Specific T Cell Activation
N. Sakato, Y. Zhao, T. Yoda, Y. Suzuki and H. Fujio

Antigen:MHC:T Cell Receptor Interaction

Molecular Basis and Functional Relevance of Peptide: Ia Interactions
A. Sette, S. Buus and H. M. Grey

Structure-Function Studies of the Class II Molecule I-Ak Using Lysozyme as a Model Antigen
E. F. Rosloniec, D. J. McKean, C. Benoist, D. Mathis and J. H. Freed

The T11 Model System for Structure/Function Analysis of the αβ T Cell Receptor
N. Shastri

Immunodominance in the T Cell Response to Lysozyme

Mechanisms Influencing the Immunodominance of T Cell Determinants in Hen Egg-White Lysozyme
L. Adorini, E. Appella and Z. A. Nagy

The Causes and Consequences of Immunodominance at the T Cell Level
R. Apple, J. Clarke, J. Cogswell, G. Gammon, M. E. Katz, U. Krzych, R. Maizels, F. Manca, A. Miller, S. Nasseri, A. Oki, S. Wilbur and E. Sercarz

The Relationship of the T Cell Response to B Cell Specificity

Paratope Interference with Processing Can Explain Selective Help for Different Epitopes in β-Galactosidase
F. Manca, D. Fenoglio, C. Cambiaggi and F. Celada

Determinant Preferences in the Relationship Between T and B Cells Specific for Lysozyme
M. Palmer and E. Sercarz

IV. B Cell Response and its Regulation

Organization of V Genes

Studies of Murine Immunoglobulin VH Repertoire by In Situ Hybridization in Unstimulated Spleen Cells
D. L. Kastner, T. M. McIntyre, C. P. Mallett, A. B. Hartman and Alfred D. Steinberg

The Immunoglobulin Kappa Light Chain (Igk-V) Gene Organization in the Mouse
L. A. D’Hoostelaere, C. P. Mallett and K. Huppi

Specificity and Idiotypy of the Response to Lysozyme

Immunological Studies on One Defined Protein Region: The “Loop” of Lysozyme
R. Arnon, M. Sela and I. Pecht

Acquisition of Affinity to a Protein Antigen with Peptide Immunization: Use of Peptide 38-54 of Hen Egg-White Lysozyme
H. Fujio, Y. Takagaki, X. Mei, Y. Uck and N. Sakato

The Primary and SecondaryAntibody Response to Lysozyme: Each Shows Distinctive Idiotypy and Restricted Epitope Recognition
A. Miller, D.-H. Hsu, C. Benjamiin, L.-K. Ch’ng, M. A. Havey, M. A. Kaplan, D. Kawahara, M. A. Keller, D. W. Metzger, L. S. Wicker and E. E. Sercarz

B Cell Specificity Repertoire During the Development of the Immune Response to Hen Lysozyme
C. P. Mallet, P. G. Rousseau, D. A. Saroff and S. J. Smith-Gill

Ontogenetic Emergence of the Response

V-Region Connectivity Determining Immune Reactivities
L. Carlsson, A. Andersson, V. Hillörn, S. Forgren, A. Coutinho and D. Holmberg

Patterns of Immunoglobulin Variable Region Expression Among Neonatal Hemagglutinin Responsive B Cells: Evidence for Nonrandom VH Gene Representation During Later Stages of Development
L. J. Kienker and M. P. Cancro

Neonatal A/J Response to HEL
M. A. Keller, G. Calandra, C. Song, S. Chang, N. S. Kenyon, M. A. Kaplan, A. Miller and E. E. Sercarz

B Cell Tolerance

Immunological Tolerance in Lysozyme/Anti-Lysozyme Transgenic Mice
C. C. Goodnow, J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, R. J. Trent and A. Basten