Book of Abstracts: Albany 2007

category image Albany 2007
Conversation 15
June 19-23 2007

Templated Synthesis of Metal -DNA Crossover Points ? Unusual Stability and Dynamic Character

Crossovers have been extensively used in DNA nanotechnology as they will provide DNA supramolecules with molecular rigidity necessary for nanomechanical devices or periodic arrays. The incorporation of transition metal as DNA crossover points would impart the resulting nanostructures with many desirable properties, such as redox and photophysical activity. Here we report the synthesis and properties of metal-bis(2,9-diphenol-1,10-phenanthroline) as the crossover point for DNA nanostructure building.

Using this method, a stable cyclic triangle DNA nano-structure junction was built at high yield This junction is unusually stable, fluorescent and has high induced CD signal. The three single strands in this junction offer possibilities to switch and modify the molecular geometry in real-time, and the template arms can be extended to form higher ordered structures

Hua Yang
Hanadi Sleiman

Department of Chemistry,
McGill University,
801 Sherbrooke St. W.,
Montreal, QC H3A 2K6, Canada Tel: 514-398-2633
Fax: 514-398-3797
Email: hanadi.sleiman@mcgill.ca
Email: hyang33@po-box.mcgill.ca