Structural genomics, the systematic determination of
all macromolecular structures represented in a genome,
is focused at present exclusively on proteins. RNA
molecules play a variety of significant roles in
cells, however, and these functions are defined by
their structures. To understand comprehensively the
biology of a cell, it will ultimately be necessary to
know the identity of all encoded RNAs, the molecules
with which they interact and their molecular
structures. Current efforts in our lab and others
focus on identifying new RNA genes and developing
strategies for predicting RNA structure. The current
state of the field and new directions will be
discussed.