Albany 2013: Book of Abstracts

category image Albany 2013
Conversation 18
June 11-15 2013
©Adenine Press (2012)

Order from disorder: Defining structure in disordered proteins

Intrinsically disordered proteins are involved in a range of functional roles in the cell, as well as being associated with a number of diverse diseases, including cancers, neurodegenerative disorders, and cardiac myopathies. We use single molecule fluorescence approaches to characterize disordered proteins implicated in the progression of Parkinson's and Alzheimer's diseases. Our goal is to understand how disease-associated modifications to these proteins alter their conformational and dynamic properties and to relate these changes to disease pathology.


This work is supported by NSF MCB 0919853.

Shana Elbaum-Garfinkle
Garrett Cobb
Abhinav Nath
Elizabeth Rhoades

Department of Molecular Biophysics & Biochemistry
Yale University
266 Whitney Avenue, Bass 234
New Haven, CT 06511

Tel: 203-432-5342
Fax: 203-432-5175