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Albany 2013: Book of Abstracts

category image Albany 2013
Conversation 18
June 11-15 2013
©Adenine Press (2012)

New Biology from Ancient Enzymes

The aminoacyl tRNA synthetases arose early in evolution to establish the genetic code during translation. Long thought of as cytoplasmic enzymes with a single defined function, new studies have demonstrated their roles in nuclear and extracellular signaling pathways, where they regulate angiogenesis, inflammation, mTor signaling, tumorigenesis, and more. These novel functions are typically associated with novel domains added to higher eukaryote tRNA synthetases, and specific resected forms that are generated by alternative splicing and natural proteolysis. The tRNA synthetases are now seen as central “nodes’’ that use their novel domains to connect with multiple cell signaling pathways through a variety of interacting partners. These partners include nuclear proteins, extracellular receptors, cytoplasmic proteins, and cellular RNAs. This new biology from tRNA synthetases is an endless frontier.


    Gou, M. & Schimmel, P. (2013). Essential nontranslational functions of tRNA synthetases. Nat Chem Biol, 9, 145-53.

    Yao, P. & Fox, P. L. (2013). Aminoacyl-tRNA synthetases in medicine and disease. EMBO Mol Med. epub date: 2013/02/22.

Paul Schimmel

The Scripps Laboratories for tRNA Synthetase Research
The Scripps Research Institute
10650 North Torrey Pines Road
La Jolla, CA 92037

Ph: (858) 784-8970
Fx: (858) 784 8990