Book of Abstracts: Albany 2003

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Conversation 13
Abstract Book
June 17-21 2003

Molecular Machines for Protein Degradation

Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic active sites are sequestered within the particles and located on the inner walls. Access of protein substrates is regulated by protein subcomplexes or protein domains which may assist in substrate unfolding dependent of ATP. Four protease machines will be described displaying different subunit structures, oligomeric states, enzymatic mechanisms, and regulatory properties.

R. Huber

Max-Planck-Institut für Biochemie
Am Klopferspitz 18a
D-82152 Martinsried, Germany

References and Footnotes
  1. Proteasome

    Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H. D. and Huber, R., Nature 386, 463-471 (1997).
    Groll, M., Heinemeyer, W., Jäger, S., Ullrich, T., Bochtler, M., Wolf, D. H. and Huber, R. Proc. Natl. Acad. Sci. USA 96, 10976-10983 (1999).
    Groll, M., Bajorek, M., Kähler, A., Moroder, L., Rubin, D. M., Huber, R., Glickman, M. H. and Finley, D. Nature Struct. Biol. 7, 1062-1067 (2000).

  2. HslV/HslU

    Bochtler, M., Hartmann, C., Song, H. K., Bourenkov, G., Bartunik, H. and Huber, R. Nature 403, 800-805 (2000).
    Song, H. K., Hartmann, C., Ramachandran, R., Bochtler, M., Behrendt, R., Moroder, L. and Huber, R. Proc. Natl. Acad. Sci. USA 97, 14103-14108 (2000).
    Ramachandran, R., Hartmann, C., Song, H. J., Huber, R. and Bochtler, M. Proc. Natl. Acad. Sci. USA 99, 7396-7401 (2002).

  3. Tricorn

    Brandstetter, H., Kim, J. S., Groll, M. and Huber, R. Nature 414, 466-470 (2001).
    Kim, J. S., Groll, M., Musiol, H. J., Behrendt, R., Kaiser, M., Moroder, L., Huber, R. and Brandstetter H. J. Mol. Biol. 324, 1041-1050 (2002).
    Goettig, P., Groll, M., Kim, J. S., Huber, R. and Brandstetter, H. EMBO J. 21, 5343-5352 (2002).

  4. DegP(HtrA)

    Krojer, T., Garrido-Franco, M., Huber, R., Ehrmann, M., and Clausen, T. Nature 416, 455-459 (2002).