Albany 2001

category image Biomolecular
SUNY at Albany
June 19-23, 2001

Molecular Dynamics Studies of a Poly dA 30-mer: Temperature Salt Effects and the Premetling Transition.

A series of molecular dynamics simulations of a 30 base pair poly dA sequence are reported for various temperature and salt conditions. Detailed analysis of these effects with respect to structure, axis fluctuations and bending, and dynamics are presented. Free energy analysis on these simulations has been prefroemed and . From the results, a possible mechanism of DNA premelting transition is suggested.

Yongxing Liu and D. L. Beveridge

Department of Chemistry and Molecular Biophysics Program Wesleyan University, Middletown CT 06459
Tel: 860-685-2777; e-mail: yliu@wesleyan.edu