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Albany 2019: 20th Conversation - Abstracts

category image Albany 2019
Conversation 20
June 11-15 2019
Adenine Press (2019)

Using Structure To Identify Protein-Protein And Drug Protein Interaction Networks

The presentation will describe the application of protein structure to predict protein-protein and protein-ligand interactions on a genome-wide scale. Protein networks and signaling pathways are constructed and described in structural terms yielding multiple potential targets for drug intervention. Drug leads are generated via structure alignment of target proteins with proteins that form a complex with small molecules where the structure is known. An integrated software package allows for the multi-directional navigation between small molecules, proteins and networks/pathways using large genomic, structural and chemical databases.

This research has been supported by NIH, 5-R01-GM030518-38

References

    Zhang, Q.C., Petrey, D., Deng, L., Qiang, L., Shi, Y., Thu, C.A., Bisikirska, B., Lefebvre, C., Accili, D., Hunter, T., Maniatis, T., Califano, A. and Honig, B. (2012) Structure-based Prediction of Protein-protein Interactions on a Genome-wide Scale. Nature 490:556 - 560.

    Zhang, Q.C., Petrey, D., Garzon, J.I., Deng, L. and Honig, B. (2013) PrePPI: A Structure-Informed Database of Protein-Protein Interactions. Nucl. Acid Res. 41:D828-833.

    Garzon, J.I., Deng, L., Murray, D., Shapira, S., Petrey, D. and Honig, B. (2016) A Computational Interactome and Functional Annotation for the Human Proteome. eLife 5:e18715

    Hwang, H., Petrey, D. and Honig, B. (2016) A Hybrid Method for Protein-Protein Interface Prediction. Prot. Sci. 25:159-165.

    Hwang, H., Dey, F., Petrey, D. and Honig, B. (2017) Structure-based Prediction of Ligand-protein Interactions on a Genome-wide Scale. Proc. Natl. Acad. of Sci. 114:13685-13690

Barry Honig

Departments of Systems Biology and Biochemistry and Molecular Biophysics
Columbia University
NY, NY 10032

Ph: (212) 851-4651
Fx: (212) 851-4650
Email: bh6@columbia.edu