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Book of Abstracts: Albany 2005

category image Volume 22
No. 6
June 2005

Studies in Vision
1. Age-related macular degeneration. 2. Rhodopsin.

1. Age-related macular degeneration (AMD).

A2E is an ocular pigment involved in age-related macular degeneration (AMD), the leading cause of blindness of person over age 55 in USA and Europe and for which no remedy exists. In addition to A2E 1, a pyridinium pigment with two retinoid side chains, several other A2E analogs 2-5 have been characterized from the eye. Photooxidation of A2E with blue light (430 nm) gives rise to an unprecedented nona-oxo derivative 5. In addition to this nona-oxo A2E 5, blue light irradiation gives rise to a complex mixture of oxidation products, some of which may damage the cell. The (S) and (R) isomers of all-trans retinal dimer 6 and 7 have been isolated from human eyes.

The genesis, interrelations of these pigments and preparation of antibodies will be discussed. The constituents of bilberry that have beneficial effects on AMD will also be presented.

Koji Nakanishi

Dept. of Chemistry
Columbia University
New York, NY 10027

Email: kn5@columbia.edu


2. Rhodopsin.

Recent studies in rhodopsin, including attempts to photo-cross-link G-protein to rhodopsin will be outlined.