Book of Abstracts: Albany 2003
June 17-21 2003
Structural Proteomics of DNA-binding Proteins from Hyperthermophilic Sulfolobus Archaebacteria
With the establishment of requisite major core facilities for modern functional genomics in Academia Sinica, we now have an excellent opportunity to study many important biological systems. The facilities include proteomics, protein expression and production, and x-ray crystallography. In our laboratory, we have used an approach of "Structural functional genomics" to analyze a number of protein systems that may be relevant in drug discovery. We will not only study single gene products, but also tackle more challenging protein-protein complexes and membrane proteins. One of our initial focuses is placed on proteins, particularly DNA-interacting proteins, from hyperthermophilic organisms. I will illustrate the progress using some recent results from our laboratory, specifically the structure of Sulfolobus DNA binding proteins Sac7d/Sso7d and Sso10b in complex with DNA.
Andrew H.-J. Wang
Institute of Biological Chemistry