Book of Abstracts: Albany 2003
June 17-21 2003
Structural and Functional Proteomics
Structural proteomics is the determination of atomic resolution 3-dimensional protein structures on a genome-wide scale in order to ascribe biochemical functions to gene products and to better understand the relationship between protein sequence, structure and function. An overview of our ongoing structural proteomics project on the non-membrane proteins from several organisms will be presented. In parallel with our structural proteomics effort have also developed an array of biochemical screens, through which we are passing each purified protein, whether or not its structure can be determined. I will discuss our cumulative results on the structural analysis of several bacterial, archeal and eucaryotic proteomes with particular emphasis on how 3-dimensional protein structure information coupled with rapid biochemical screens of novel or uncharacterized proteins can be a powerful tool for biochemical annotation of a genome. Examples of new insights into protein function and the relationship between structure and sequence will also be presented.
Cheryl H. Arrowsmith
Ontario Cancer Institute and