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Book of Abstracts: Albany 2005

category image Volume 22
No. 6
June 2005

Simulation of RNA Structure and Dynamics

The solution structure of RNA encompasses a multitude of sequence- and environment-dependent conformations. The dynamic equilibrium of these states is crucial to their biological function. Examples will be given to illustrate (i) how a mismatch incorporated in a duplex affects time-scales of base opening motions, (ii) how simulated loop structures match up to measured NMR parameters, and (iii) how external petrurbations influence the structure of an RNA junction.

Peter Varnai

Department of Chemistry
Lensfield Road
Cambridge, CB2 1EW
United Kingdom

Phone: +44 1223 336 311
Fax: +44 1223 336 362
Email: pv232(at)cam.ac.uk