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Albany 2019: 20th Conversation - Abstracts

category image Albany 2019
Conversation 20
June 11-15 2019
Adenine Press (2019)

Seeing the structure of RNA-binding proteins in membraneless organelles and disease-associated aggregates

Nicolas Fawzi, Brown University, leads a team using NMR spectroscopy, molecular simulation, microscopy, and cell assays to probe disordered protein domain assembly and function. Disordered domains of RNA binding proteins aggregate in several neurodegenerative diseases and mediate formation of functional, liquid, membraneless organelles. Nick's group probes the structure of these protein (including TDP-43, FUS, hnRNPA2) within in vitro models of these organelles, the mechanistic structural changes due to disease-causing mutations, the ability of post-translational modification to alter assembly.

Nicolas Lux Fawzi

Molecular Pharmacology
Physiology & Biotechnology
Brown University
70 Ship Street, Box G-E
Providence, RI, 02912-G

Email: nicolas_fawzi@brown.edu