Book of Abstracts: Albany 2003
June 17-21 2003
Protein Structure: Missing Basics to Proteomic Code
The recent discovery of universal structural units of globular proteins, closed loops of standard size 25-30 amino acid residues have led to the representation of globular proteins as linear assemblies of loop elements (1). The loop organization of proteins is dictated by the physics of polypeptide chains, and should have been imposed on protein structure at the earliest stages of protein evolution (2). The earliest proteins were presumably loop-like, with the contour length about 30 residues. Modern globular structures contain descendants of these ancient prototypes, and later can be reconstructed from the analysis of complete proteomes. The first prototypes of this kind were identified and their representatives in crystallized proteins have closed loop structure (3). A full spectrum of the sequence/structure prototypes may serve as a ?proteomic code?; an alphabet for the decoding of protein sequences and characterization of the respective globular structures.
Igor N. Berezovsky
Department of Structural Biology