Albany 2013: Book of Abstracts
June 11-15 2013
©Adenine Press (2012)
Orientational ordering of short DNA fragments in the polymer matrix
As a vital part of modern nanotechnology, nanofabrication aims to develop nanoscale components and nanomaterials in large quantities at relatively low cost. The promising strategy is the bottom-up self-assembly techniques of chemical assembly and molecular recognition to bring together individual atoms, molecules, or supramolecular building blocks to form useful constructs. The DNA-DNA self-assembly seems to be the key point regulating the polymer composites formation.
We address the mixture of a flexible polymer with short double-strand DNA fragments, where the persistence length in comparable with the contour length of the molecule. We investigate the conditions affecting the orientational order formation of short double-strand DNA fragments, immersed in the flexible polymer. It is shown that short double-strand DNA fragments exhibit the formation of a liquid crystalline ordered phase, in dependence on the value of the Flory-Huggins parameter, aspect ratio and the attraction energy (Mamasakhlisov et al., 2009; Todd et al., 2008) of the double strand DNA molecules and volume fraction of polymer.
B.A. Todd, V.A. Parsegian, A. Shirahata, T.J. Thomas, & D.C. Rau (2008). Attractive Forces between Cation Condensed DNA Double Helices. Biophys J. 94 , doi:10.1529/biophysj.107.127332).
Zareh A. Grigoryan 1
1Department of Electronics of Goris State University