Albany 2013: Book of Abstracts

category image Albany 2013
Conversation 18
June 11-15 2013
©Adenine Press (2012)

Orientational ordering of short DNA fragments in the polymer matrix

As a vital part of modern nanotechnology, nanofabrication aims to develop nanoscale components and nanomaterials in large quantities at relatively low cost. The promising strategy is the bottom-up self-assembly techniques of chemical assembly and molecular recognition to bring together individual atoms, molecules, or supramolecular building blocks to form useful constructs. The DNA-DNA self-assembly seems to be the key point regulating the polymer composites formation.

We address the mixture of a flexible polymer with short double-strand DNA fragments, where the persistence length in comparable with the contour length of the molecule. We investigate the conditions affecting the orientational order formation of short double-strand DNA fragments, immersed in the flexible polymer. It is shown that short double-strand DNA fragments exhibit the formation of a liquid crystalline ordered phase, in dependence on the value of the Flory-Huggins parameter, aspect ratio and the attraction energy (Mamasakhlisov et al., 2009; Todd et al., 2008) of the double strand DNA molecules and volume fraction of polymer.


    Y. Sh. Mamasakhlisov, B. A. Todd, A. V. Badasyan, A. V. Mkrtchyan, V. F. Morozov, & V. A. Parsegian (2009). DNA stretching and multivalent-cation-induced condensation. Phys. Rev. E 80, 1-9.

    B.A. Todd, V.A. Parsegian, A. Shirahata, T.J. Thomas, & D.C. Rau (2008). Attractive Forces between Cation Condensed DNA Double Helices. Biophys J. 94 , doi:10.1529/biophysj.107.127332).

Zareh A. Grigoryan 1
Yevgeni Sh. Mamasakhlisov2
Armen T. Karapetian3

1Department of Electronics of Goris State University
Avangard 2,
Goris 3201, Armenia
2Department of Biophysics
Yerevan State University
Aleq Manukyan 1
Yerevan 0025, Armenia
3Department of Physics and Electrical Engineering
Yerevan State University of Architecture and Construction,
Yerevan 0009, Armenia

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