Book of Abstracts: Albany 2003

category image Albany 2003
Conversation 13
Abstract Book
June 17-21 2003

Molecular Construction with DNA and Metal Nanoparticles: Applications in Molecular Nanotechnology and DNA Chip Detection

Metal nanoparticles are structures with interesting optical and electronical properties. Due to the small size, defined manipulation of these particles (e.g. positioning) is difficult. To overcome this problem, self-assembly processes based on bioconjugated nanoparticles and surfaces were proposed.

We develop techniques for specific positioning of individual nanoparticles on electronic chip surfaces using complementary DNA (1). As an example for possible electronic applications, a scheme and first realized steps towards a single-electron tunneling transistor using this approach will be presented. This includes the positioning of individual molecules of lambda-DNA in an electrode gap.

Beside such rather far-reaching visions, DNA-nanoparticle complexes have an interesting application already today as potential complement (or maybe even replacement) label in DNA chip technology. Work towards an optical (2) and electrical (3) detection of nanoparticle DNA on a solid substrate demonstrated the feasibility of this approach. An electrical detection system based on a resistive principle, using a microstructured chip with a DNA array, nanoparticle-labeled DNA and an autonomous readout device, was realized (4).

W. Fritzsche
A. Csaki
G. Maubach
R. Möller
A. Sondermann

Institute for Physical High Technology
PO Box 100239
07702 Jena, Germany

References and Footnotes
  1. Csáki, A., Maubach, G., Born, D., Reichert, J. and Fritzsche, W. Single Molecule, 3, 275-280 (2002).
  2. Reichert, J., Csáki, A., Köhler, J. M. and Fritzsche, W. Analytical Chemistry 72, 6025-6029 (2000).
  3. Möller, R., Csáki, A., Köhler, J. M. and Fritzsche, W. Langmuir 17, 5426-5430 (2001).
  4. Urban, M., Möller, R. and Fritzsche, W. Review of Scientific Instruments 74, (in press) (2003).