Albany 2001

category image Biomolecular
SUNY at Albany
June 19-23, 2001

Mechanisms of DNA Unlinking and Chromosome Segregation

During replication, the two strands of DNA must be separated, copied, and partitioned into daughter cells. Three huge motor proteins, helicases, topoisomerases, and condensins, reshape DNA to achieve chromosome unlinking and segregation with astonishing speed and fidelity. I will summarize our recent work on how these proteins work and on the nature of the long-range folding of DNA in bacterial cells. I will highlight the utility of new methods involving single molecule enzymology and genetic microarrays.

Nicholas. R. Cozzarelli, Alexander Alexandrov, Nancy Crisona, Carlos Bustamante, Zev Bryant, Christine Hardy, Victor Holmes, Brian Peter, Lisa Postow, Michael Stone, Alexander Vologodskii*

Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720 * Department of Chemistry, New York University, Washington Square, New York, NY 10003
Ph: 510-643-6363; fx: f 510-643-1079; email: cdea@socrates.berkeley.edu