SUNY at Albany
June 19-23, 2001
Map of Z-DNA in Human Chromosome 22
Although Z-DNA was discovered over 20 years ago, its function in a broad biological context remains largely undefined. We have subjected the sequence of human chromosome 22 to a rigorous thermodynamic search for this left-handed conformation using an extended version of the program Z-Hunt. The location of each potential Z-DNA forming region are compared relative to all the relevant markers for gene function, including known genes, pseudogenes, and open reading frames, and the relative positions within the genes and their exons and introns. The resulting map allows us to correlate this unusual structure with the functional elements of the human genome.
Christopher Chámp, Tracy Camp and P. Shing Ho
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA