Albany 2015:Book of Abstracts
June 9-13 2015
©Adenine Press (2012)
Nobel Laureate Phillip Sharp
The 21st Century opened with a revolution in RNA Biology
The discoveries of RNA interference and the evolutionary conservation of microRNAs at the turn of the century heralded a revolution in RNA Biology and the development of important innovations. Of particular note is the emerging understanding of the wide ranging roles of non-coding RNAs. Long non-coding RNAs regulate the expression of genes through both cis and trans mechanisms and provide organization to the nucleus. Small non-coding RNAs channel gene expression to specific states and suppress transposon elements. Excitingly, these insights and others are now being translated into new treatments for diseases and control of plant pathogens.
Phillip A. Sharp
Koch Institute for Integrative Cancer Research