Book of Abstracts: Albany 2009
June 16-20 2009
© Adenine Press (2008)
Graphical Modeling of the Beta-Globin Transcription Factory
Biology provides more and more 3D representations of molecules at work in cells. Those fundamental units of life most often work together to achieve the specific task they are assigned to. In this context, the huge amount of structural data available has now to be integrated into a unified view of the macromolecular complexes they form. We would like to propose here a structure of the machinery designed to transcribe our genes into messenger RNA. This structure has been termed "transcription factory". The structure of most of its parts is now resolved at different resolutions using a broad array of techniques such as X-rays diffraction patterns of proteins/nucleic-acids crystals and electron microscopy of complexes. Transcription factories are ∼100 nm diameter protein-rich units from which loops of DNA emanates. Three to eight polymerase II are estimated to reside on their surface. We propose here a unified plausible structure of one of this unit located within the 11nth of our chromosomes.
1Laboratoire de Physique Théorique de la Matière Condensée