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Conversation 11: No. 1

category image Volume: Conversation 11
Issue Number 1
May 2000
ISBN 0-940030-80-2

Globularity and Protein Function

The forces that direct protein folding lead naturally to native proteins and protein domains that are typically, to a first approximation, globular?spherical and compact, with a relatively clear distinction between the hydrophobic inside and polar outside. The near-universality of these features of protein structures sharpens our focus on some apparent exceptions. Consideration of the structure/function link in some of the exceptional cases provides some insights into our views of protein function.

Jannette Carey

Chemistry Department
Princeton University
Princeton, NJ 08544-1009

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