Book of Abstracts: Albany 2009
June 16-20 2009
© Adenine Press (2008)
Function and evolution of the genomic code for nucleosome positioning
The detailed positions of nucleosomes along genomes have critical roles in transcriptional regulation. Consequently, it is important to understand the principles that govern the organization of nucleosomes in vivo, and the functional consequences of this organization. I will present our progress in identifying the functional consequences of nucleosome organization, in understanding the way in which nucleosome organization is encoded in the DNA, and in linking the two, by suggesting that distinct transcriptional behaviors are encoded through the genome?s intrinsic nucleosome organization. Our results thus provide insight on the broader question of understanding how transcriptional programs are encoded in the DNA sequence. Finally, I will also show that a major phenotypic diversity among yeast species is accompanied by corresponding DNA sequence changes that alter the DNA-encoded nucleosome organization, suggesting that such changes may be a novel genetic mechanism for achieving phenotypic diversity across evolution.
Department of Computer Science And Applied Mathematics