Book of Abstracts: Albany 2003
June 17-21 2003
Expanding Protein Universe and its Origin From the Biological Big Bang
The bottom up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we discover peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we discover that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.
Nikolay V. Dokholyan
Department of Biochemistry and Biophysics