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Book of Abstracts: Albany 2011

category image Albany 2011
Conversation 17
June 14-18 2011
©Adenine Press (2010)

Enzyme-catalyzed DNA Cytidine Deamination in Human Biology

Over the past decade, we have learned that humans have ten DNA cytidine deaminases that catalyze a variety of physiological functions from triggering antibody gene diversification to providing innate immunity to a broad number of foreign DNA elements such as viruses and transposons. I will review the biology of these enzymes and discuss recent biochemical and structural advances that help us to better appreciate their integral cellular functions (1-4)

This research has been supported by NIH grants R01 GM080437, R01 AI064046, R03 MH089432 and R21/R33 AI073167.

References
  1. Shandilya, S.M.D., M.N.L. Nalam, E.A. Nalivaika, P.J. Gross, J.C. Valesano, K. Shindo, M. Li, M. Munson, E. Harjes, T. Kouno, H. Matsuo, R.S. Harris, M. Somasundaran & C.A. Schiffer, Structure, 18, 28-38 (2010).
  2. Stenglein, M.D., M.B. Burns, M. Li, J. Lengye, R.S. Harris, Nature Structural and Molecular Biology, 17, 222-229 (2010).
  3. Refsland, E.W., M.D. Stenglein, K. Shindo, J.S. Albin, W.L. Brown, R.S. Harris, Nucleic Acids Research, 38, 4274-84 (2010).
  4. Shlyakhtenko, L.S., A.Y. Lushnikov, M. Li, L. Lackey, R.S. Harris, Y.L. Lyubchenko, Journal of Biological Chemistry, 286, 3387-95 (2011).

Reuben S. Harris

Department of Biochemistry, Molecular Biology & Biophysics University of Minnesota – Twin Cities Minneapolis & Saint Paul, MN 55455

Ph: (612) 624-0457
Fx: (612) 625-2163

rsh@umn.edu