19th-banner-rev.gif

DNA Double Helix

category image

DNA Double Helix & the Chemistry of Cancer
Hardcover 1988

Editors: Ramaswamy H. Sarma, Ph.D. & Mukti H. Sarma, Ph.D.

ISBN 0-940030-26-8

DNA Double Helix & the Chemistry of Cancer

Ramaswamy H. Sarma, Ph.D. & Mukti H. Sarma, Ph.D.

Preface
Suggested Reading Materials

Chapter I: DNA is the Genetic Material

Background
The Early Years
Transformation

Chapter 2: Chemistry of Nucleic Acid Bases

Molecules with Single Bonds
Molecules with Double Bonds
Nucleic Acid Bases
Mutation
Mutation Induced by Sub Light
Mutation Due to Tautomerism
Mutation Due to Modification of Bases
Mutation Due to Intercalation

Chapter 3: Asymmetry, Amino Acids and Proteins

Introduction
Asymmetric Carbon Atoms
The Protein Amino Acids
The Planar Peptide Linkage
The Secondary Structure of Proteins
The Tertiary Structure of Proteins
The Quarternary Structure of Proteins
Folding Structural Motifs in a Protein
Sickle Cell Anmeia
Disassembly of Protein
Glycoproteins and Glycolipids

Chapter 4: Construction of DNA and RNA

Sugar Pucker and Internal Motions
The Nucleosides
The Anti and Syn Conformations
The Nucleotides
Phosphodiester Linkages in DNA and RNA
The Chain Direction, 5'→3'
Internal Rotattions Within the Chains
The Palindromes
The Tetranucleotide Hypothesis
The High Energy Phosphates
DNA Replication

Chapter 5: Structure of DNA

Intrpoduction
The B DNA
Base Pairs in B DNA
Vertical Distance Between Base Pairs
Pitch of the Helix
B DNA is a Right-Handed Helix
In B DNA the Bases are in the Center
In B DNA Glucosyl Torsion is Anti
In Many Sequences Base Pairs are Flat
Propeller Twisted Base Pairs in B DNA
Minor and Major Grooves
Factors that Stabilize B DBA
The Z DNA
Z DNA and B DNA: A Comparison
B DNA <-> Z DNA Transition
The A DNA
Bent and Curved DNA’s
DNA Rings
Cruciforms and Hairpins
DNA Junction and Networks
Hoogsteen Base Pairing
DNA with Mismatched Base Pairs
The Triple Helix
DNA-Drug Complexes
Intercalation
Covalent Binding
The Groove Binding Drugs
Why Know the Stucture of Drug-DNA Complexes?
DNA Structure in the Chromosomes
The Nucleosome
The Chromatin Fiber
Effect of Campaction on DNA Function

Chapter 6: DNA Directed Protien Synthesis

Introduction
The Ribosomes
Messenger RNA and the Genetic Code
Recognition by RNA Polymerase II
Processing of Messenger RNA
Transfer RNA’s
Ribosomal RNA
The Synthesis of Protein
The Central Dogma
Effect of Drugs on Transcription and Translation
Control of Gene Expression
Conformational Change and Methylation
Differential RNA Processing & Evolution
Summary of the Switch Mechanism
The Components of Master Switch
The Switch is Turned On
The Effect of UV Light on the Switch
Genetic Engineering
Restriction Endonulceases
Cloning and Recombinant DNA
Gel Electrophoresis
DNA Sequencing

Chapter 7: The Cell

Nucleus
Mitochondria
Microsomes
Golgi Bodies
Vacuolers
Cell Division
Mitosis
Meiosis

Chapter 8: The Virus

Life Cycle of the DNA Virus
Life Cycle of the RNA Virus
Retrovirus

Chapter 9: The Immune System

The Lymphocytes
Immune Response
Antibody or Immunoglobulin
Clonal Theory of Antibody Production
Maturation of T Lymphocytes
Destruction of Target Cells
Primary and Secondary Response to Antigen
Immunologic Tolerance
Autoimmunity

Chapter 10: Cancer

What is Cancer?
How can Slightly Different DNA Cause Cancer?
Mutation
Mutation During Cross-Over
Mutation by Physical Means
Mutation by Chemical Means
Active Radicals
Virus as Cancer Causing Agent
How Do Viruses Cause Cancer?
Cancer and Chromosomes
Cancer is a Multistage Process
Initiation
Promotion
Progression
Metastatsis
Mechanism of Tumor Invasion
Inherited Basis for Cancer
Carcinogenic Chemicals in Food
Anticarcinogens in Food
Life Style, Environment and Cancer
Aging and Cancer
Why Everybody Does Not get Cancer?

$50.00