Book of Abstracts: Albany 2011
June 14-18 2011
©Adenine Press (2010)
Disordered proteins in Parkinson's and Alzheimer's Disease: Linking structural transformations to function, aggregation and toxicity.
The proteins tau and alpha-synuclein are linked to neurodegenerative disease both through their appearance within protein-rich deposits in diseased brain and through the identification of mutations in their associated genes which cause hereditary forms of disease. Both protein share the property of being highly disordered when isolated in solution, but both proteins can undergo disorder-to-order transitions either upon interactions with appropriate binding partners or upon aggregating into fibrillar amyloid-like aggregates similar to those found in brain deposits. Structural studies of these proteins provide the basis for new hypothesis regarding how their structural transformations may mediate both the normal function of these proteins, as well as they pathological aggregation.
Department of Biochemistry