Book of Abstracts: Albany 2009
June 16-20 2009
© Adenine Press (2008)
Dendritic DNA Molecules: Towards Controllable Nanomaterials
DNA has been widely used as a building block in nanoscience to construct self-assembled structures due to it?s? ease of functionalization, programmability and molecular recognition properties. Although discrete 2D and 3D nanostructures have been assembled from DNA building blocks, long range assembly is still problematic.
On the other hand, block copolymers achieve long range morphology control often by using amphiphilic building blocks that microphase separate under various conditions. However, block copolymers cannot achieve the molecular control and recognition properties of DNA nanostructures.
We herein report the synthesis of a building block that combines the programmability of DNA with the long range morphologies achieved by block copolymers. Specifically, we have synthesized a dendritic DNA (D-DNA) molecule containing oligethylene glycol (PEG) dendrons that self-assembles into fibers with microns in length.