Book of Abstracts: Albany 2005
Could We Consider a Cell as a Device with a Set of Right Organized Crystalline Ribosomes?
Modern molecular biology considers different levels of organization of macromolecules in cells. Four levels of protein structure organization are known. We would like to look at organization of the cell itself and to consider the cell as a higher level of organization, like fifth, sixth, seventh, et cetera. There are up to 20,000 ribosomes in a prokaryotic cell. They account for up to 80% of RNA of prokaryotic cell and 10% of cell protein. It is difficult to imagine that such tremendous amounts of ribosomes exist and move in cells chaotically. Electron microscopy studies of ribosome crystals (1) have shown that tetramers are the main unit of ribosome crystals. Looking at interaction of ribosomes with m-RNA, we can not only consider ribosomes moving on messenger RNA, but m-RNAs moving through the set of right organized crystalline tetrameric ribosomes, like some motor pulling the m-RNA strand from one end. We will discuss such a model of cell organization.
References and Footnotes
Center for Biophysical Sciences and Engineering