Book of Abstracts: Albany 2011
June 14-18 2011
©Adenine Press (2010)
Computational Approach to Unravel Molecular Events During Vitiligo
Vitiligo is an acquired depigmenting autoimmune disorder characterized by the loss of functional melanocytes from the epidermis. The pathomechanism of the disease is unpredictable because of multifactorial and overlapping mechanisms. Vitiligo involves complex interaction of environmental and genetic factors that ultimately contribute to melanocyte destruction, resulting in the characteristic depigmented lesions. There is no agreement about the pathomechanisms involved in the disappearance of melanocytes to form the characteristic achromic lesions. Several hypothesis have been developed for pathogenesis, but none of the hypothesis enlighten the path followed during the disorder. Therefore to construct a map of molecular interactions of the vitiligo disease is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of vitiligo, based on the protein-protein interaction network using String 8.0. The map reveals that the overall architecture of the pathway is a bow-tie structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).
Key Words: Vitiligo, CellDesigner, String, Protein-Protein Interaction Network