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Albany 2019: 20th Conversation - Abstracts

category image Albany 2019
Conversation 20
June 11-15 2019
Adenine Press (2019)

Influence of Low-Intensity Millimeter Waves on Lipid Peroxidation and Antioxidant Enzymes Activity in Male Wistar Rats

Electromagnetic waves of millimeter range (MM EMW) correspond to the extremely-high-frequency (EHF) electromagnetic irradiation (EMI) band (f =30-300 GHz) always exist in surrounding environment and intensively influence living organisms. It has been suggested that initial cellular event affected by exposure to EMI might be the increase of free radical level, which may enhance lipid peroxidation (LPO) and antioxidant enzymes activity (Ramundo Orlando, 2010). The investigation concerned with the effect of low-intensity MMW on whole body exposure of male Westar rats. Twenty rats were divided into two groups: sham-exposed (control) and experimental (10 animals each). Animals were exposed with 50.3 GHz frequency EMI (power flux density 64mWt/cm2 ) for 1h/day, for 5 days (day after day). As a source of monochromatic EMI EHF generator G4-141 type with working interval of 37.50-53.57 GHz (State Scientific-Production Enterprise “Istok”, Russia) was used. The whole body specific absorption rate (SAR) was 0,05 W/kg. Exposure took place in a ventilated plexiglas cage, where rats could move inside given space. After completion of each exposure period, rats were sacrificed to analyze malondialdehyde (MDA)-rate and enzyme activity (catalase and glutathione peroxidase) in brain, liver, heart and skeletal muscle. Our findings indicate a significant increase (P<0,05) in level of MDA and CAT activity in brain of EMI-exposed group of animals as compared to sham-exposed, depending on EMI exposure duration. At the same time, we recorded slightly elevated MDA-rate in experimental animals liver in comparison with the control group. The MDA values concerning heart and skeletal muscles remained at the same levels in the EMI- exposed rats and did not differ significantly from control. Data show a significant decrease of GPX activity in experimental rats brain (P< 0,001) and liver (P< 0,05), whereas CAT activity significantly increased in the same organs compared to control. Studied indexes may indicate possible health implications of such exposure and should be taken into account.

References

Ramundo-Orlando A. (2010), Effects of Millimeter Waves on Cell Membrane-A Brief Review, J. Infrared Milli Terahz Waves, 31, 1400-1411.

Gayane H. Poghosyan
Marieta S. Mikaelyan
Anahit V. Nerkararyan

Department of Biophysics
Yerevan State University
Yerevan, Armenia

Ph.: (+374 60) 710-522
Email: g.poghosyan@ysu.am