Issue December 2008
Volume 26No. 3 (p 273-402) December 2008 ISSN 0739-110 Synthesis, Characterization, and DNA-binding Properties of Ln(III) Complexes Containing Gatifloxacin (p. 293-300)Four novel water-soluble complexes of Ln(III) with gatifloxacin (HGA), [La(HGA)3Cl3]·2H2O, [Nd(HGA)3Cl3]·2H2O, [Eu(HGA)3Cl3]·2H2O, [Tb(HGA)3Cl3]·2H2O, have been synthesized and characterized by elemental analyses, molar conductivities, IR spectra, fluorescence spectra, and thermogravimetry/differential thermal analysis (TG-DTA). In addition, the DNA-binding properties of the ligand and its complexes have been investigated by absorption, fluorescence spectra, and viscosity measurements. The experimental results indicated that the complexes and ligand bind to DNA via groove binding mode.
Key words: Gatifloxacin; Ln(III) complexes; DNA-binding. Tonghuan Liu College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry Subscription is more cost effective than purchasing PDFs on-the-fly. Click here for details. |
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