Issue December 2007

category image Volume 25
No. 3 (p 207-326)
December 2007
ISSN 0739-110

Using Recurrence Quantification Analysis Descriptors for Protein Sequence Classification with Support Vector Machines (p. 289-298)

In this work, we integrate a non-linear signal analysis method, recurrence quantification analysis (RQA), with the well-known machine-learning algorithm, support vector machines for the binary classification of protein sequences. Two different classification problems were selected, discriminating between aggregating and non-aggregating proteins and mostly disordered and completely ordered proteins, respectively. It has also been shown that classification performance of SVM models improve on selection of the most informative RQA descriptors as SVM input features.

Joydeep Mitra
Piyushkumar Mundra
B. D. Kulkarni*
Valadi K. Jayaraman*

Chemical Engineering and Process Development Division
National Chemical Laboratory
Dr. Homi Bhabha Road
Pune 411 008, India
*bd.kulkarni@ncl.res.in vk.jayaraman@ncl.res.in

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