A nucleosome DNA sequence probe is designed that combines recently derived RR/YY counter-phase and AA/TT in-phase periodical patterns. A simple nucleosome mapping procedure is introduced for prediction of the nucleosome positions in the sequence of interest, to serve as a guide for experimental studies of the chromatin structure.

Key words: Nucleosome positioning; Nucleosome sequence patterns; Nucleosome mapping; Alternative nucleosome positions; and Sequence periodicity.