Plant disease resistance (R) genes, the key players of innate immunity system in plants encode ?R? proteins. ?R? protein recognizes product of avirulance gene from the pathogen and activate downstream signaling responses leading to disease resistance. No three dimensional (3D) structural information of any ?R? proteins is available as yet. We have reported a ?R? gene homolog, the ?VMYR1?, encoding ?R? protein in Vigna mungo. Here, we describe the homology modeling of the ?VMYR1? protein. The model was created by using the 3D structure of an ATP-binding cassette transporter protein from Vibrio cholerae as a template. The strategy for homology modeling was based on the high structural conservation in the superfamily of P-loop containing nucleoside triphosphate hydrolase in which target and template proteins belong. This is the first report of theoretical model structure of any ?R? proteins.

Key words: Vigna mungo; Resistance genes; ?R? protein; ABC transporter; Homodimer; and Homology modeling.