Issue October 2004

category image Volume 22
No. 2 (p 119-252)
October 2004
ISSN 0739-110

Ligand Binding With Continuous Modification of Binding Sites (p. 245-252)

Simultaneous formulation binding and structure modification of the binding site leads to binding process that can be analyzed within the framework of the non-linear theory of dynamic systems. Such an approach allows us to obtain several properties of the binding center: plurality of stationary (stable and unstable) states at binding, recognition of bistable and hysteretic binding modes. It is also shown that adsorption centre deformation leads to a S-shaped adsorption curve.

V. B. Arakelyan1*
S. G. Haroutiunian2
H. H. Abgaryan3
A. V. Arakelyan2
T. S. Haroutunyan2

1Yerevan Physics Institute
Alikhanian Brothers Str.2
Yerevan, 375036 Armenia
2Physics Department
Yerevan State University
Al. Manoogian Str.1
Yerevan, 375049, Armenia
3Yerevan State Medical University
Koryun Str.2
Yerevan, 375025, Armenia
*arakelv@uniphi.yerphi.am

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