Issue October 2004
Volume 22No. 2 (p 119-252) October 2004 ISSN 0739-110 Interactions of 5-deazapteridine Derivatives with Mycobacterium tuberculosis and with Human Dihydrofolate Reductases (p. 119-130)There are major differences between the structures of human dihydrofolate reductase (hDHFR) and Mycobacterium tuberculosis dihydrofolate reductase (mtDHFR). These differences may allow us to design more selective mtDHFR inhibitors. In this paper we study the reactions of six different compounds derived from 5-deazapteridine with human and bacterial enzymes. Results suggest that the addition of hydrophobic groups to the aminophenyl ring would increase mtDHFR-inhibitor affinity and selectivity.
Key words: Mycobacterium tuberculosis, DHFR, Simulation study, Docking. Elaine F. F. da Cunha1* 1Instituto de Quimica da Universidade Federal do Rio de Janeiro ? UFRJ Subscription is more cost effective than purchasing PDFs on-the-fly. Click here for details. |
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