Issue December 2002

category image Volume 20
No. 3 (p 311-486)
December 2002
ISSN 0739-1102
An Opinion Piece: Conversation on Levinthal Paradox & Protein Folding #5

What is Paradoxical about Levinthal Paradox? (p. 327-330)

We would be tempted to state that there has never been a Levinthal paradox. Indeed, Levinthal raised an interesting problem about protein folding, as he realized that proteins have no time to explore exhaustively their conformational space on the way to their native structure. He did not seem to find this paradoxical and immediately proposed a straightforward solution, which has essentially never been refuted. In other words, Levinthal solved his own paradox.

Marianne Rooman*
Yves Dehouck
Jean Marc Kwasigroch
Christophe Biot
Dimitri Gilis

Ingénierie Biomoléculaire
Université Libre de Bruxelles
CP 165/64, 50 avenue Roosevelt
B-1050 Bruxelles, Belgium
*mrooman@ulb.ac.be

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