Issue April 2001

category image Volume 18
No. 5 (p 647-782)
April 2001
ISSN 0739-1102

Interactions of Meso-tetra-(4-N-oxyethylpyridyl) Porphyrin, its 3-N Analog and Their Metallocomplexes with Duplex DNA (p. 677-688)

Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin (TOEPyP(4)), its 3-N analog (TOEPyP(3)) and their Co, Cu, Ni, Zn metallocomplexes with duplex DNA have been investigated by uv/visible absorbance and circular dichrosim spectroscopies. Results reveal the interactions of these complexes with duplex DNA are of two types. (1) External binding of duplex DNA by metalloporphyrins containing Zn and Co, and (2) Binding of duplex DNA both externally and internally (by intercalation) by porphyrins not containing metals, and metalloporphyrins containing Cu and Ni. Results indicate that (4N-oxyethylpyridyl) porphyrins intercalate more preferably in the structure of duplex DNA and have weaker external binding than 3N-porphyrins.

Yeva B. Dalyan1
Samvel G. Haroutiunian1*
Gayane V. Ananyan1
Volodya I. Vardanyan1
Dmitri Y. Lando2
Valeri N. Madakyan3
Robert K. Kazaryan3
Luigi Messory4
Pierluigi Orioli4
Albert S. Benight5

1Chair of Molecular Physics
Department of Physics
Yerevan State University
1, Al.Manoogian St.
375025 Yerevan, Armenia
2Institute of Bioorganic Chemistry
Belarus National Academy of Sciences
Kuprevich St. 5/2
220141 Minsk, Belarus
3Chair of Pharmacological Chemistry
Yerevan State Medical University
2, Korun St.
375025 Yerevan, Armenia
4Department of Chemistry
University of Florence
Via G. Capponi, 7
50121 Florence, Italy
5Department of Chemistry
(M/C 111)
Science and Engineering
South University of Illinois at Chicago
845 West Taylor Street
Room 4500
Chicago, Il 60607-7061, USA
*Molekfiz@ysu.am

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