Book of Abstracts: Albany 2005
Biosensing by Hybridization Chain Reaction
Single-stranded DNA is a versatile construction material that can be programmed to self-assemble into nanoscale devices driven by the free energy of base pair formation. Triggered self-assembly can be achieved using the mechanism of hybridization chain reaction (HCR), in which metastable DNA monomers assemble only upon exposure to a target DNA fragment. This functionality allows DNA to act as an amplifying transducer for biosensing applications.
References and Footnotes
Niles A. Pierce
Applied & Computational Mathematics and Bioengineering