Book of Abstracts: Albany 2005

category image Volume 22
No. 6
June 2005

Biosensing by Hybridization Chain Reaction

Single-stranded DNA is a versatile construction material that can be programmed to self-assemble into nanoscale devices driven by the free energy of base pair formation. Triggered self-assembly can be achieved using the mechanism of hybridization chain reaction (HCR), in which metastable DNA monomers assemble only upon exposure to a target DNA fragment. This functionality allows DNA to act as an amplifying transducer for biosensing applications.

References and Footnotes
  1. R. M. Dirks and N. A. Pierce Proc Natl Acad Sci 101 15275-15278, (2004).

Niles A. Pierce

Applied & Computational Mathematics and Bioengineering
California Institute of Technology
Mail Code 114-96
Pasadena, CA 91125

Phone: 626 395 8086
Fax: 626 395 8845
Email: niles@caltech.edu