Conversation 11: No. 2
Volume: Conversation 11
Issue Number 2
An Earring for the Double Helix: Assembly of Topological Links Comprising Duplex DNA and a Circular Oligodeoxynucleotide
Novel DNA nanostructures, locked pseudorotaxane and locked catenane were assembled through topological linkage of a double-stranded target to a circular oligodeoxyribonucleotide (cODN)+. The formation of these supramolecular complexes occurs with remarkable sequence specificity and is accomplished via local opening of duplex DNA by a pair of homopyrimidine bis-PNAs. The obtained cODN label, resembling an earring, forms a true topological link with the linear or closed circular (cc) target DNA and occupies a fixed position along the double helix. The PNA directed assembly described here introduces PNA oligomers into the repertoire of DNA nanotechnological tools.
Center for Advanced Biotechnology
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