Albany 2015:Book of Abstracts
June 9-13 2015
©Adenine Press (2012)
A novel role for astrocytes in regulating glutamate clearance during stroke
Astrocytes play a crucial role in regulating the extracellular concentration of neurotransmitters under basal conditions and during ongoing synaptic events. Glutamate transporters are abundantly expressed on the cell membrane of astrocytes and generate currents that can be monitored by obtaining patch-clamp recordings from astrocytes. The activity of astrocytic glutamate transporters is modulated by intracellular signaling pathways, but it remains unclear how blood extravasation from the vasculature affects the glutamate uptake capacity of astrocytes. Here we show that there are rapid structural and functional changes in astrocytes that can be triggered by experimental conditions that mimic brain hemorrhage and that can lead to changes in synaptic function. These findings provide novel insights into the molecular mechanisms underlying brain dysfunction during hemorrhagic stroke.